金尔伦治疗急性颅脑损伤的剂量效应研究

Dose-response effect of naloxone on acute brain injury in rats

目的 探讨金尔伦 (盐酸纳洛酮 )在治疗大鼠液压脑损伤后神经功能恢复和病理损害程度的剂量效应。方法 将 10 4只SD大鼠随机分为 4组 ,伤后早期分别腹腔注射 0 .0 3mg/Kg(小剂量组 )、0 .3mg/Kg(中剂量组 )、3mg/Kg(大剂量组 )金尔伦和等量生理盐水 (对照组 ) ,连续 7d。结果中、大剂量组动物伤后脑神经功能恢复、脑水肿减轻程度及光、电镜检查显著优于对照组及小剂量组。结论 伤后早期使用中剂量和大剂量金尔伦 (盐酸纳洛酮 )

Objective To investigate the effect of dose response of naloxone on severe fluid percussion brain injury in rats.Methods One hundred and four SD rats were randomly divided into four groups, 0.03 mg/kg (low dose group), 0.3 mg/kg (moderate dose group), 3 mg/kg(high dose group) of naloxone and saline(control group) were injected transperitoneally once a day for 7 days after injury.Results Moderate and high dose of naloxone significantly improved the recovery of neurofunction, increased the survival of neurons in the hippocampus and alleviated brain edema as well, compared to low dose group and control group.Conclusion Early application of moderate or high dose of naloxone is effective to improve the outcome of traumatic brain injury .