老年脑出血患者对氧磷酯酶1基因192位Gln-Arg多态性的研究

The relationship between the gene polymorphism in paraoxonase 1 and cerebral hemorrhage in the elderly

目的 探讨对氧磷酯酶 1(PON1)基因 192位Gln Arg(Q R192 )多态性与老年脑出血的关系。方法 本研究采用病例对照设计 ,对 170例脑出血患者 (脑出血组 )和 2 0 4例健康体检者 (对照组 )进行研究。采用聚合酶链反应 限制性片段长度多态性方法测定PON1Q R192基因多态性。结果 在脑出血组中 ,PON1Q R192 3种基因型频率分别为QQ12 .4 %、QR5 0 .6 %和RR37.1%。PON1Q R192基因型和等位基因频率分布在脑出血组与对照组间差异无显著性意义 ;各基因型之间血脂水平差异无显著性意义。结论 PON1Q R192基因多态性与老年脑出血不存在相关关系。

Objective To investigate the correlation between the paraoxonase Gln-Arg 192 polymorphism (PON1Q/R192)and cerebral hemorrhage in the elderly. Methods This was a case-control study, which enrolled 170 cases of cerebral hemorrhage and 204 elderly healthy controls. Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1Q/R192.Results The PON1Q/R192 genotype distribution in the cerebral hemorrhage group studied was QQ 12.4%, QR 50.6% and RR 37.1%, respectively. There was no significant difference in PON1Q/R192 allele and genotype distribution between the cerebral hemorrhage group and the control group. No significant association between Q/R192 genotype and the profile of blood lipids was detected.Conclusion These results suggest that the PON1Q/R192 gene polymorphism is not associated with cerebral hemorrhage in the elderly.