尿NAG、RBP的变化在肾功能正常的肾病患者中的应用

Application of Urinary-N-acetyl-beta-D-glucosaminidase and Retinoid-binding Protein in Nephropathic Patients with Normal Kidney Function

目的 探讨肾功能正常的肾小球和肾血管疾病患者尿 NAG、RBP的变化 ,以确定在上述患者中尿 NAG和 RBP的应用价值。方法 选择肾功能正常的慢性肾小球肾炎患者 ( CGN) 2 0例、原发性肾病综合征 ( NS)未缓解期患者 1 8例、高血压肾损害患者 ( HN) 1 0例、糖尿病性肾病患者 ( DN) 2 0例 ,分别进行尿NAG/尿肌酐、RBP检测 ,并与 1 2例正常人对照。结果 与正常组相比 ,各肾脏病组尿 NAG/尿肌酐、RBP均有不同程度升高 ,以 NS组最明显。结论 肾小球和肾血管疾病在出现肾功能减退之前 ,即可能存在一定程度的肾小管 -间质损伤 ,从而在尿 NAG和 RBP的变化中反映出来。

Objective To investigate the renal tubular and i nterstitial lesion in glomerulopathy and renal vascular diseases with normal ren al function.Methods The levels of urinary-N-acety1-bet a-D-glucosaminidase(NAG) by NAG/urinary creatinine (Ucr) and retinoid-binding protein(RBP) were detected in 80 persons (including 20 chronic glomerulonephrit is, 18 primary nephrotic syndrome without clinical remission,10 hypertensive nep hropathy,20 diabetic nephropathy,and 12 normal persons).Results The urinary NAG/Ucr and RBP in four observed groups were highter than hea lthy control group,particularly in NS group.Conclusion Gl omerulopathy and renal vascular diseases should be coexistenced by renal tubular and interstitial lesion before chronic renal failure.