地尔硫联合美托洛尔治疗混合型心绞痛的疗效观察

The effect of diltiazem associated with metoprolol on the patients with mixed angina pectoris

目的 观察地尔硫 艹卓 与美托洛尔联合治疗混合型心绞痛的疗效及安全性。方法 选择 31例常规口服阿斯匹林 ,硝酸酯类 ,美托洛尔 2周疗效不好的混合型心绞痛患者 ,后两周加用地尔硫 艹卓 ,采用自身前后对照方法 ,共 4周 ,观察心绞痛症状 ,心电图及心功能的变化。结果 (1)合用地尔硫 艹卓 后心绞痛发作次数明显减少 ,持续时间明显缩短。 (2 )缺血性ST -T明显改善。 (3)加用地尔硫 艹卓 前后心功能无显著性变化。(4 )出现 2例窦性心动过缓 ,经调整用药后恢复。结论 混合型心绞痛患者联合应用地尔硫 艹卓 及美托洛尔是安全有效的。

Objective To investigate the effect and safety of diltiazem associated with metoprolol in treating mixed angina pectoris . Methods 31patients with mixed angina pectoris who had been treated with aspirin , nitrate and metoprolol for two weeks but unable to get better, were given diltiazem for another two weeks. The frequencies and degree of angina pectoris ,ECG and cardiac functions before and after diltiazem given were contrasted in the patients.Results (1) The onest frequecy and the duration of angina after diltiazem given were significantly decreased .(2) The apparent improvement of ischemic ST-Ts were observed. (3) There weren't change of cardiac functions in the patients before and after diltiazem given . (4) Sinus bradycardia occured in two patients after diltiazem given ,and then recovered by making adjustment of dosages of diltiazem .Conclusion Diltiazem associated with metoprolol for the patients with mixed angina pectoris is effective and safe.