阿拓莫兰治疗慢性乙型肝炎260例疗效观察

CLINICAL OBSERVATION ON TREATMENT OF CHRONIC HEPATITIS B WITH ATUOMOLAN

目的 :观察还原型谷胱甘肽 (商品名为阿拓莫兰 )对慢性乙型病毒性肝炎的疗效。方法 :5 0 5例慢性乙型肝炎按病情程度分为轻、中、重度三型 ,各型分别按随机抽样方法分为治疗组 2 6 0例 (轻度 4 6例 ,中度 15 8例 ,重度 5 6例 ) ,对照组 2 4 5例 (轻度 4 2例 ,中度 15 0例 ,重度 5 3例 )。对照组采用B族维生素 ,维生素C ,复方丹参注射液 ,肌苷注射液等静脉滴注。治疗组在此基础上加用阿拓莫兰 12 0 0mg静脉滴注 ,每日 1次治疗。疗程 30天。观察症状、体征及治疗前后监测肝功指标。结果 :对慢性乙型病毒性肝炎中、重度治疗组肝功能指标改善优于对照组 (P<0 .0 0 1,P <0 .0 0 1) ;治疗有效率也较对照组高 (P <0 .0 0 5 ,P <0 .0 2 5 )。结论 :阿拓莫兰是一种重要的抗氧化剂 ,能维护肝细胞膜稳定性 ,可作为病毒性肝炎治疗用药。

Objective: To explore the clinical effect of ATuoMoLan (Reduced Glutathione) on chronic hepatitis B. Methods: 505 cases of chronic hepatitis B patients were divided into mild, moderate and severe types. By means of random sampling, each type was subdivided into two groups: The treatment group included 260 patients(46 cases, mild; 158 cases, moderate;56 cases,severe). The control group included 245 patients(42,150,53,respectively). The latter was treated with Vitamin B, Vitamin C, Danshenzhusheye and Inosine injection. The former was treated with ATuoMoLan additionally in dose of 1200mg per day. The duration of treatment was 30 days. The variation of symptoms and hepatic biochemical index was observed. Results: The improvement of hepatic biochemical index of chronic hepatitis B of moderate and severe types in the treatment group was better than that of the control group (P<0.001, P<0.001), and the effective rate was higher than that of the control group (P<0.005,P<0.025,respectively). Conclusion: Reduced Glutathione is an important antioxidant, which can keep the stability of hepatocellular membrane. and so it can be advisably applied to treat chronic hepatitis B clinically.