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神经细胞粘附分子结构特征和生理功能 被引量：4

The structure and physiological function of neural cell adhesion molecules
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摘要 神经细胞粘附分子是一类调节细胞与细胞、细胞与细胞外基质间粘附作用的膜表面糖蛋白,主要有NCAM-180、NCAM-140、NCAM-120三种形式,多与PSA结合在一起。在神经系统中,NCAM的表达具有时间和空间特异性,最主要的作用为调节神经系统的可塑性,这种作用可能是通过PSA-NCAM对AMPA的调节作用,主要是通过调节蛋白激酶的表达和细胞内Ca2+浓度来实现的。 Neural cell adhesion molecules(NCAMs) are cell surface glycoproteins that appear to mediate cell-cell,cell-extracellular matrix adhesion. NCAMs, largely attached with polysialic acid(PSA), exist in three majordifferent polypeptide forms with apparent molecular weight 180, 140, 120kD. In nervous system, NCAM isexpressed in a defined temporal and spatial pattern. PSA-NCAM plays an important role in the formation of neuralplasticity by regulating AMPA receptor formation, mainly by regulating the expression of the protein kinase andthe intracellular Ca2+ level.
作者 邓朝晖 余争平 王登高
机构地区 第三军医大学预防系劳动卫生教研室
出处 《生命科学》 CSCD 2004年第5期285-287,共3页 Chinese Bulletin of Life Sciences
关键词 神经细胞粘附分子 AMPA受体 neural cell adhesion molecule AMPA receptor
分类号 Q513.2 [生物学—生物化学]
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参考文献11

  • 1Becker C G, Artola A, Gerardy-Schahn R, etal. Thepolysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation. J Neurosci Res, 1996, 45(2): 143～152
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  • 4Jessen U, Novitskaya V, Pedersen N, et al. The transcription factors CREB and c-Fos play key roles in NCAM-mediated neuritogenesis in PC 12-E2 cells. J Neurochem, 2001, 79(6):1149-1160
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二级参考文献16

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二级引证文献8

生命科学
2004年 第5期

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