摘要
血脑屏障使许多具有中枢神经活性的药物无法到达脑部发挥作用,非侵入性脑内给药因对机体无创伤而受到研究者广泛关注。本文介绍了血脑屏障的物质转运系统以及经鼻粘膜、渗透性血脑屏障开放、纳米粒载体和转运载体法等非侵入性脑内给药方法的机制和特点。
The blood-brain barrier (BBB) restricts the transport action and action of many central neuroactivedrugs in the brain.Thus the non-invasive drug delivery to brain has been following with great interest. In thispaper, the mechanism and characteristics of the non-invasive drug delivery through nasal mucosa, osmoticopening of the BBB, nanoparticulate and transporter vectors is introduced and discussed.
出处
《生命科学》
CSCD
2004年第5期292-295,共4页
Chinese Bulletin of Life Sciences
关键词
血脑屏障
药物转运
非侵入性
blood-brain barrier
drug delivery
non-invasive
