过度训练对大鼠各组织谷氨酰胺代谢的影响及谷氨酰胺干预的研究

The Effect of Overtraining and Supplement Glutamine on the Glutamine Metabolism of the Tissues in Rats

目的 :探讨过度训练大鼠各脏器组织谷氨酰胺 (Gln)的代谢变化及Gin的干预作用。方法 :采用过度训练大鼠模型 ,通过补充Gln对比试验 ,应用高效液相色谱技术 ,观察过度训练后大鼠血浆及各组织中Gln含量的变化。结果 :单纯运动组大鼠血浆 ,肌肉、肝脏、肺脏Gln含量与安静对照组比较 ,明显减少 (P <0 0 )补充Gln运动组大鼠血浆及各组织Gln含量与安静对照组比较 ,下降不明显 (P >0 0 5 ) ,与单纯训练组比较 ,显著升高。结论 :过度训练状态下大鼠血浆及各组织Gln含量显著下降 ,补充外源性的Gln能有效的维持过度训练状态下机体Gln的正常代谢。

Objective the aim of this study was to examine the effect of overtraining and supplement glutamine on the glutamine of the tissues in rats Methods the concentration of glutamine was determined by high-per for mance liquid chromatography after overtianing and supplement glutamine Results The results showed that overtraining induced marked reduction of glutamine concentration in tissues and blood Overtraining with glutamine can maintain the glutamine concentration in tissue sand improve the glutamine concentration in tissues and blood Conclusions Overtraining induced obvious reduction of glutamine concentration in tissues and blood Supplemenet glutamine can maintain the glutamine metabolism