纳米材料在组织工程中的应用研究

The present status of application of nanomaterials in tissue engineering

组织工程研究领域中,支架材料与细胞的相互作用是主要的研究课题。支架材料表面的微观结构对细胞的生物调控作用更为重要。纳米材料因具有一些独特的效应,如体积效应和表面效应,有利于细胞的粘附、增殖和功能的增强,因而作为组织工程支架有良好的应用前景。目前用于组织工程研究的纳米材料主要有无机纳米材料、高分子纳米材料、复合纳米材料,仿生纳米材料的研究和利用将极大地促进组织工程学的发展。本文就近年来纳米材料的制备方法以及其在组织工程中的应用研究现状进行了综述。

The study of scaffold material-cell interactions was the major subject in the field of tissue engineering. Micro-structured surfaces of materials had more remarkably biological control on cells. As scaffold materials, nanomatreials have a perfect perspective for their particular effects such as space effect and surface effect, which could enhance biologic activity, adhesiveness and proliferation of cells. At present, inorganic nanomateri-als, macromolecular nanomaterials and compound nanomaterials are the major materials researched in tissue engineering. The investigation and utilization of biomimetic nanamaterials will promote the development of tissue engineering effectively. In this article, we review the up-to-date study of preparation and application of nanomaterials in tissue engineering.