手性配体DDPPI-Pd(Ⅱ)催化α-烯烃不对称氢酯基化反应的研究

Chiral Diphosphine Ligand DDPPI-Pd(Ⅱ) Catalyzed Asymmetric Hydroesterification of α-Olefins

考察了手性双膦配体DDPPI在钯催化1 辛烯及官能化端烯的不对称氢酯基化反应中的手性诱导作用,最高得到了45.2%的ee值.其中在1 辛烯的不对称氢酯基化反应中,考察了不同的膦 钯比、反应温度、压力、不同的溶剂、不同的钯催化剂前体以及助催化剂对反应的影响.其中膦 钯比在2～4的范围内,催化反应获得了较高的光学产率;以丙酮作溶剂,得到较好的催化效果.

A chiral diphosphine ligand DDPPI has been applied to catalytic asymmetric hydroesterification of olefins and asymmetric induction up to 45.2%e.e. has been obtained .Here, the influences of P/Pd ratio, temperature, pressure, solvents and cocatalysts on the reaction have been investigated. The reaction result was better when P/Pd ratio was in the range of 2～4 and the solvent was acetone.