人海马胚胎发育的超微结构研究

Neuronal development of hippocampus in human fetus

电子显微镜下观察了15～30周人胎海马CA3区神经元的发育。结果表明:随着胎龄增大,核内异染色质减少,染色质分散。线粒体和粗面内质网等细胞器的数量随增龄而增加。随着树突和树棘的生长.细胞间隙中的神经毡日益丰满。突触的三大基本结构清晰可辩,早期以对称型突触稍多,以后发现非对称型突触居多。提示:20周以前的细胞较少分化,可选作供体,用于海马移植研究。

The development of the neurons of hippocampal field CA3 in the human fetuses of 15 to 30 weekswas studied under electronic microscope. The results were as follows. As the hippocampus progressed,the heterochromatin decreased and dispersed,and the number of rough endoplasmic reticulum and mito-chondria increased. As the dendrite and dendritic spine grew,the neuropil between cells became large.The structures of synaptic contact were seen clearly. There were more symmetric synaptic contact atthe early stage and more asymmetric synaptic contact at the later stage.