重症肌无力病人胸腺提取液对人淋巴细胞增殖的影响

Effect of thymus extract from patients with myasthenia gravis on normal human lymphocyte proliferation

用~3H-TdR掺入法观察了不同稀释度的重症肌无力病人胸腺提取液(TEMG)对成人外周血淋巴细胞增殖的影响。结果表明:1:5稀释度的TEMG对植物血凝素(PHA)诱导的人淋巴细胞增殖与空白对照相比有明显的抑制作用(P<0.001),而对正常未经PHA诱导的淋巴细胞增殖无影响,当稀释度为1:500时,TEMG对PHA诱导的人淋巴细胞增殖有明显的促进作用(P<0.05)。提示:TEMG有人胚胸腺素类物质存在。

The effect of thymus extract of various concentrations from the patients with myasthenia gravis(TEMG) on normal human lymphocyte proliferation was evaluated with ~3H-TdR incorporation as-say. The results showed that TEMG diluted to 1: 5 possesed significant suppressive effect (P<0. 001) on PHA-induced normal human peripheral blood lymphocyte (PBL) proliferation. When theconcentration was diluted to 1: 500,TEMG presented significant enhancement on PHA-induced nor-mal human PBL proliferation. These results show there is similar human embryo thymin in TEMG.