替代光气进行有机合成的化学方法

The Methods of Synthesizing Organic Substances by Substitution Phosgene

综述了目前取代剧毒原料光气进行有机合成的12种有价值的绿色化学方法,以典型的合成路线为基础,介绍了其优缺点、发展现状及存在的问题,得出结论:碳酸二甲酯的方法是当前最为廉价且已有大规模生产的方法,三光气、碳酸乙烯酯取代光气也取得了一定的成绩,而一氧化碳羰基化有很好的前景,但需在催化剂方面作进一步研究。

In this paper, twelve environmentally benign methods which can substitute the toxic gas phosgene to synthesize organic substances are summarized, and the advantages and disadvantages, development and the existent problems are introduced. Conclusion: Using dimethel carbonate (DMC) to substitute phosgene is the lowest - cost method that has already had cosmically production; The studying of ethylene carbonate and triphosgene have also obtained achievements in degree; the carbonyl method of carbon monoxide has a promising future, but should study in the catalytic systems deeply.