牙周引导组织再生术与植骨术联合应用的临床研究

Clinical Study on Guided Tissue Regeneration Combined with Bone Grafts.

目的 比较引导组织再生术 (GTR)和植骨术联合应用的方法与单纯GTR的方法在牙周骨内袋缺损中的疗效。方法 治疗 16例患者的 4 4个骨内袋缺损 ,其中 2 3个相似的病损联合应用了GTR加植骨术 ,而在 2 1个病损中进行了GTR术 ,疗效评价直至术后 12个月。结果 两组的手术区域 ,与术前基线比较 ,在术后 3、6、12个月观察到的临床参数如附着水平、探诊深度以及菌斑指数、探诊出血均有明显改善 (P <0 .0 0 1)。两组之间比较 ,结果无显著性差异 (P >0 .0 5 )。结论 在牙周手术中 ,植入骨代用品与GTR联合应用 ,比较单纯应用GTR方法的临床疗效没有显著性差异。

Objective To compare the effects of guided tissue regeneration (GTR) combined with bone grafts and simple GTR in the treatment of intrabony periodontal defects. Methods 44 intrabony defects were treated on 16 patients. In 23 lesions, GTR and bone grafts were performed, while in 21 lesions, only GTR was performed. Results were evaluated over a time span of 12 months. Results In all surgical areas significant improvements can be observed in the 3 rd , 6 th and 12 th month after operation, which are reflected on parameters such as attachment levels and probing depths,as well as index values for plaque and bleeding on probing. Comparing the collective results of both treatment groups, no significant difference is seen whether bone grafts had been done or not. Conclusion Combining transplantation of bone substitute with GTR during periodontal surgery for the enhancement of tissue regeneration in intrabony pockets is not more effective than GTR only statistically.