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子宫内膜癌CD44v6的表达及意义 被引量：2

Expression of CD44 variant 6 in endometrial cancer and its clinicial significance
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摘要 目的:研究子宫内膜癌的CD44v6的表达与子宫内膜癌浸润转移的关系。方法:应用免疫组织化学SP法检测50例子宫内膜 癌的CD44v6的表达情况。结果:在有淋巴结转移组中,CD44v6阳性表达率明显低于无淋巴结转移组(P<0.05),但其与子宫内膜癌的 组织学类型、病理分级、临床分期及癌组织浸润肌层深度无关。结论: CD44v6的低表达可促进子宫内膜癌的淋巴结转移。 Objective: To study the relationship between CD44v6 expression and nodal metastasis in endometrial cancer. Methods: CD44v6 in 50 endometrial carcinomas was detected by S-P immunohistochemical method. Results:Although CD44v6 was down-expressed in the case of lymph node metastasis, its expression was not correlated with histological types, pathological grading, clinical stages, and myometrial infiltration. Conclusion:The down-expression of CD44v6 could promote nodal metastasis in endometrial cancer.
作者 梁艳艳 郑朝晖
机构地区 广东医学院附属医院妇产科 广东医学院附属医院病理科
出处 《广东医学院学报》 2004年第5期441-442,共2页 Journal of Guangdong Medical College
关键词 子宫内膜癌 CD44V6 低表达 淋巴结转移 阳性表达率 癌浸润转移 组织学类型 CD44v6 immunohistochemistry endometrial carcinoma
分类号 R737.33 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献7

  • 1Hoshimoto K,Yamauchi N,Takazawa Y,et al.CD44 variant 6 in endometrioid carcinoma of the uterus: its expression in the adenocarcinoma component is an independent prognostic marker[J].Pathol Res Pract,2003,199(2):71-77.
  • 2Stiokes GN,Shelton JB Jr,Zahn CM,et al.Association of CD44 isoform immunohistochemical expression with myometrial and vascular invasion in endometrioid endometrial carcinoma[J].Gynecol Oncol,2002,84(1):58-61.
  • 3Ayhan A,Tok EC,Bildirrici L,et al.Overexpression of CD44 variant 6 in human endometrial cancer and its prognostic significance[J].Gynecol Oncol,2001,80(3):355-358.
  • 4Stameakovic I,Aruffo A,Amoit M.The henatopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells [J].Embo J,1991,10(2):343-348.
  • 5Mackay CR,Terpe HJ,Stauder R,et al.Expression and modulation of CD44 variant isoforms in humans [J].J Cell Biol,1994,124:71.
  • 6Gunthert U,Hofmann M,Rudy W,et al.A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells[J].Cell,1991,65(1):13-24.
  • 7蔡斌,万小平.CD44在妇科肿瘤中的研究进展[J].国外医学（妇产科学分册）,2003,30(5):313-316. 被引量：2

二级参考文献19

  • 1Skubitz AP. Adhesion molecules. Cancer Treat Res, 2002,107:305-329.
  • 2Ponta H, Sherman L, Herrlich PA. CD44:from adhesion molecules to signalling regulators. Nature Rev Mol Cell Biol, 2003, 4(1):33-45.
  • 3Jeffrey S, Ross MD, Christine E, et al. Decreased CD44 standard form expression correlates with prognostic variables in ovarian carcinomas. Am J Clin Pathol, 2001,116:122-128.
  • 4Bemer HS, Davidson B, Bemer A, et al. Expression of CD44 in effusions of patients diagnosed with serous ovarian carcinoma--diagnostic and prognostic implications. Clin Exp Metastasis, 2000, 18(2): 197-2O2.
  • 5Sancho-Tortes I, Mesonero C, Miller Watelet JL et al. Clear cell carcinoma of the ovary: characterization of its CD44 isoform repertoire.Gynecol Oncol, 2000,79(2): 187-195.
  • 6Stickeler E, Vogl FD,Denkinger T, et al. Soluble CD44 splice variants and pelvic lymph node metastasis in ovarian cancer patients. Int J Mol Med, 2000, 6(5):595-601.
  • 7Sanchez Lockhart M, Hajos SE, Basilio FM, et al. Splice variant expression of CD44 in patients with breast and ovarian cancer. Oncol Rep, 2001, 8(1):145-151.
  • 8Concin N, Hefler L, van Bavel J,et al. Biological markers in pT1 and pT2 ovarian cancer with lymph node metastases. Gynecol Oncol,2003, 89(1):9-15.
  • 9Bourguignon LY, Zhu H, Zhou B,et al. Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac 1 and Ras signaling during ovarian tumor cell migration and growth. J Biol Chem, 2001, 276(52):48679-48692.
  • 10Casey RC, Oegema TR Jr, Skubitz KM,et al. Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells. Clin Exp Metastasis, 2003, 20(2):143-152.

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广东医学院学报
2004年 第5期

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