1%盐酸特比萘芬乳膏治疗浅部真菌感染的疗效观察

The Effectiveness of Terbinafine Hydrochloride Cream in Treating Superficial Fungal Infections: A Clinical Observation

目的 :观察 1 %盐酸特比萘芬乳膏治疗浅部真菌感染的疗效及安全性。方法 :对门诊 78例经临床及真菌镜检诊断为股癣 ,手足癣及花斑癣的病人 ,每天 2次使用 1 %盐酸特比萘芬乳膏外搽 ,疗程 2周 ,治疗开始及治疗结束 2周后进行症状及体征评分和真菌学镜检 ,治疗结束随访时同时对病人进行满意度调查。共对随访资料完整的 78例病人的治疗结果进行了总结。结果 :1 %盐酸特比萘芬乳膏治疗手足癣的总有效率为 94 1 % ,对股癣总有效率为 96% ,对花斑癣总有效率为 89 5 %。病人总体满意度方面表示非常好和很好的比例为 84 6%。没有记录到治疗有关的副作用。结论 :1 %盐酸特比萘芬乳膏治疗皮肤真菌感染具有很高的临床有效率及依从性 ,安全性高 。

Objective:To observe the effectiveness and safety of terbinafine hydrocbloride cream in the treatment of superficial fungal infection. Methods:terbinafine hydrochloride cream was applied twice daily for 2 weeks to patients with tinea cruris, tinea manuum and pedis and pityriasis versicolor. The clinical features as well as microscopic fungi examination were evaluated at the beginning of therapy and 2 weeks after therapy. A questionnaire survey about the cost, safety, patients-assessment about the cream was also done at the end of treatment. Results:The total effective rate for tinea manuam and pedis was 94.1%, 96% for tinea cruris and 89.5% for pityriasis versicolor. For questionnaire survey, 84.5% patients gave terbinafine hydrochloride cream “excellent” or “very good” assessment. No report on side effects. Conclusion:terbinafine hydrochloride cream demonstrated its highly clinical as well as microbial effectiveness in treating superficial fangal infections. It is safe and easy for patients to use. We highly recommended it as the first line therapy for cutaneous fungal infection.[