摘要
本实验给大鼠肌肉注射地塞米松（０．１ｍｇ／１００ｇ体重），分别喂食低钙饲料和高钙饲料，观察大鼠骨灰重，骨密度，骨组织学形态及体内雌二醇，ＰＧＥ２、１，２５－（ＯＨ）２－Ｄ３和ｃＡＭＰ的变化。结果表明，低钙组大鼠骨盆丢失明显，且血中雌二醇，１，２５－（ＯＨ）２－Ｄ３下降，而ＰＧＥ２和ｃＡＭＰ则升高。高钙组大鼠则无上述变化，接近正常大鼠水平，说明钙剂可对抗地塞米松对骨代谢的影响。
In this experiment we gave rats dexamethasone by intramuscular injection and low calcium or high calcium food to observe, eight weeks later, the changes of estradiol, PGEZ, 1, 25-(OH)2-D3 and cAMP in blood and bone metabolism. As a result,the rats fed with low calcium food developed osteoporosis. In these rats, the estradiol and 1, 25-(OH)2-D3 decreased, while PGE2 and cAMP increased. The rats fed with high calcium food did not exhibit these changes,suggesting that calcium could resisted the effect of dexamthasone on bone metabolism.
出处
《中国骨质疏松杂志》
CAS
CSCD
1997年第3期61-63,88,共4页
Chinese Journal of Osteoporosis
基金
国家自然科学基金
