有机磷农药对过氧化脂质及肾功能的影响

EFFECTS OF ORGANOPHORUS PESTICIDE POISONING AND ITS RESCUE ON LIPID PEROXDASE AND RENAL FUNCTION.

目的 :探讨有机磷农药对过氧化脂质 (L po)、肌酐 (Cr)、尿素氮 (BU N)的影响。方法 :采用敌百虫急性中毒模型 ,测定其中毒及解救过程中 L po、 Cr、 Ach E (胆硷酯酶 )含量。结果 :有机磷农药中毒及注射阿托品解救后 ,L po明显增高 ,使用解磷定 (PAM) 30 m in后 ,L po明显降低 ;L po变化与 Ach E呈负相关性 ;Cr、 BU N在中毒及解救中变化很少。结论 :有机磷农药中毒时 L po有显著增高 ,L po变化与 Ach E呈负相关性。

Objective:To explore the effects of orgemophorus pesticide on lipid peroxidase(Lpo),creatinine(Cr) and blood urea nitrpogen(BUN).Methods:The animal samples of acutely poisoned by dipterex poison were used to measure the content of Lpo,Cr and cholinesterase(AchE) in the poisoning and rescue course.Results:Lpo was rised obviousty in the poisoning and rescue with the injection of atropine and Lpo was reduced with the action of pralidoxime(PAM) after 30 minutes.The negative correlation between the changes of Lpo and AchE and little changes of Cr and BUN were indicated.Conclusion:The changes of Lpo and AchE is negative correlation.