接种乙肝疫苗对人群HBVM模式的影响

THE INFLUENCE OF HEPATITIS B VACCINATION TO THE MODEL OF HEPATITIS B VIRUS ARKERS.

目的 :了解乙肝疫苗接种以来 ,山东省人群中乙肝感染指标和感染模式的变化情况 ,为评价疫苗免疫预防效果 ,制订乙肝防治策略提供依据。方法 :采用多级分层整群随机抽样的方法 ,抽取全省 11个县 (市区 )的 74 19人进行了乙肝疫苗接种情况的调查 ,并用固相放射免疫法检测其乙肝血清学指标。结果 :人群乙肝疫苗接种率为 2 8.2 1%。 HBs Ag、抗- HBs总阳性率分别为 5 .0 5 %、 4 5 .2 6 % ,其中未接种组为 5 .88%、 36 .14 % ,接种组为 2 .96 %、 6 8.4 7%。两组差异均有统计学意义 (P<0 .0 1)。抗 - HBs阳性率城市均高于农村 (P<0 .0 1)。结论 :接种乙肝疫苗能有效的提高抗 - HBs阳性率 ,减少乙肝病毒感染率 ,是控制乙肝发病的有效措施。

Objective:To understand change of hepatitis B virus markers and their model after hepatitis B vaccination,to judge effect of hepatitis B vaccination and to provide basis for modifying hepatitis B preventive policy according to the change.Methods:Using multi-stage stratified cluster random sampling,7 419 normal people were selected and investigated.Their sera were tested for HBsAg,anti-HBs and anti-HBc by using RIA.Results:Immunization rate of hepatitis B vaccine was 28.21%.HBsAg,anti-HBs total positive rates were 5.05%,45.26% respectively,in which they were 5.88%,36.14% in no hepatitis B vaccination group and 2.96%,68.47% in hepatitis B vaccination group.There is significant difference between two groups(P<0.01).HBsAg positive rate was higher among males than females in no vaccination group,but it was reverse in other group.It also was higher among people who lived in country in no vaccination group,but there were no difference in immunization group.There were higher anti-HBs positive rates among people who lived in urban areas in two groups.There were significant differences in HBsAg and anti-HBs positive rate among region interior of each group.Conclusion:Hepatitis B vaccination can effectively increase anti-HBs positive rate,decrease infective rate of hepatitis B virus.So that it is a availably measure for controlling incidence of hepatitis B.