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转染Smad2基因的大鼠肾系膜细胞Ⅰ、Ⅲ型胶原表达的改变 被引量：1

Changes of Type Ⅰ、Ⅲ Collagen Expression on Cultured Rat Mesangial Cells Transfected with Smad2 Vector
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作者 于鸿 汪怡 王小刚 许杰 赵仲华 张秀荣 郭慕依
机构地区 复旦大学上海医学院病理学系
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2004年第5期538-539,共2页 Fudan University Journal of Medical Sciences
基金 上海科学技术发展基金资助项目 ( 0 1JC14 0 18)
关键词 改变 表达 肾系膜细胞 SMAD2 Ⅲ型胶原 大鼠 转染 基因 糖胺聚糖 病理过程
分类号 R692 [医药卫生—泌尿科学] R619.6 [医药卫生—外科学]
  • 相关文献

参考文献8

  • 1Poncelet AC, DE Caeolecker MP, Schnaper HW. The transforming growth factor-β/SMAD signaling pathway is present and functional in human mesangial cell. Kidney Int, 1999,56:1354
  • 2Grande J. Role of transforming growth factor in tissue injury and repair. Proc Soc Exp Bio, 1997,214:27
  • 3Zimmerman CM, Padgett RW, Schnaper HW. Transforming growth factor-β signaling mediators and regulators. Gene, 2000,249:17
  • 4Border WA, Nobel NA. TGF-β1 in kidney fibrosis:a target for gene therapy. Kidney Int, 1997,51:1388
  • 5Dennler S, Itoh S, Vivien D, et al. Direct binding of Smad3 and Srnad4 to critical TGF-βinducible elements in promoter of human plasrninogen activator inhibitor-type 1 gene. EMBO J, 1998,17: 3091
  • 6Chen SW, Leveneon AS, Mori Y, et al. Stimulation of type I collagen transcription in human skin fibroblast by TGF-β:involvement of Smad3. J Invest Dermatol , 1998,112:49
  • 7Hayashida TH, Poncelet AC, Hubchak SC, et al. TGF-β1 activates MAP kinase in human mesangial cells: A possible role in collagen expression. Kidney Int, 1999,56:1710
  • 8Janknecht R,Wells Nj ,Hunter T:TGF-β-stimulated cooperation of Smad protein with the coactivators CBP/P300.Gene Der, 1998,12:2153

同被引文献15

  • 1Poncelet AC,de Caestecker MP,Schnaper HW. The transforming gowth factor-beta /SMAD signaling pathway is present and functional in human mesangial cells. Kidney Int,1999,56:1354-1365.
  • 2Moustakas A,Souchelnytskyi S,Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci,2001,114(Pt 24):4359-4369.
  • 3Poucelet AC,Schnaper HW. Regulation of human mesangial cell collagen expression by transforming growth factor beta 1. Am J Physiol,1998,275(3 Pt 2):F458-F466.
  • 4Boider WA,Nobel NA. TGF-beta in kidney fibrosis: a target for gene therapy. Kidney Int,1997,51:1388-1396.
  • 5Massague J,Watton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J,2000,19:1745-1754.
  • 6Verrecchia F,Chu ML,Mauviel A. Indentification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem,2001,276:17058-17062.
  • 7Piek E,Ju WJ,Heyer J,et al. Functional characterization of transforming growth factor beta signaling in Smad 2- and Smad3-deficient fibroblasts. J Biol Chem,2001,276:19945-19953.
  • 8Li JH,Zhu HJ,Huang XR,et al. Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad 2 activation. J Am Soc Nephrol,2002,13:1464-1472.
  • 9Hayashida T,Poncelet AC,Hubchak SC,et al. TGF-beta1 activates MAP kinase in human mesangial cell:a possible role in collagen expression. Kidney Int,1999,56:1710-1720.
  • 10Zdunek M,Silbiger S,Lei J,et al. Protein kinase CK2 mediates TGF-beta1 -stimulated type Ⅳ collagen gene transcription and its reversal by estradiol. Kidney Int,2001,60:2097-2108.

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复旦学报（医学版）
2004年 第5期

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