硫酸镁、硫酸舒喘灵交替使用治疗早产临床观察

Clinical observation of alternative use of magnesium sulfate and sulfuric acid to cure the prematurity

目的 探讨硫酸镁、硫酸舒喘灵交替使用在早产治疗中的作用。方法 对硫酸镁、硫酸舒喘灵交替使用组 (2 1例 )及单独使用硫酸镁对照组 (2 1例 )进行疗效观察。结果 两组显效时间分别为 (30 .0 6± 1 5 .76 ) m in及(35 .2 6± 1 7.32 ) m in;保胎成功率分别为 90 .5 % (1 9/ 2 1 )例及 6 6 .7% (1 4 / 2 1例 ) ,前者比后者效果显著 (P<0 .0 5 ) ;硫酸镁小剂量使用保胎效果较差 ,剂量过大可引起呼吸停止 ,心脏骤停 ;硫酸舒喘灵可引起心动过速 ,甚至心肌缺血、肺水肿等。本组引起不良反应前者为 2例 (9.5 % ) ,后者为 1 0例 (4 7.6 % ) ,两者差异有显著性 (P<0 .0 5 ) ;新生儿分娩时孕周、体重、Apgar评分差异也有显著性 (P<0 .0 5 )。结论 硫酸镁和硫酸舒喘灵交替使用治疗早产效果显著 ,副作用少 。

Objective To discuss the medical function of using magnesium sulfate and sulfuric acid alternately in premature treatment.Methods Two groups were setup,one alternatively using the medicines and the other only using magnesium.The curative effects were observed and analysed.Results The effect time of the two groups were(30.06±15.76) min and (35.26±17.32) min.The success rate of embryo protection was 90.5%(19/21 cases) and 66.7%(14/21) cases.The former had more curative effects than the latter( P <0.05).Too small amount of magnesium sulfate brought little effect in embryo protection,but too large amount of it can cause breath ceasing and sudden heart stopping.The sulfuric acid can cause heavy breath,and even the myocardial blood deficiency and pulmonary edema etc.As for the harmful effects,the former had two cases(9.5%) and the latter had ten cases(47.6%).There were striking differences between them( P <0.05).Conclusion Using magnesium sulfuric and sulfuric acid alternately in premature treatment has more curative effects and less side effects.They are initial medicines for embryo protection.