仙鹤草降血糖的实验研究

An Experimental Study of the Hypoglycemic Effect of Herba Agrimoniae in Mice

目的 :研究仙鹤草对小白鼠血糖的影响。方法 :分别对正常、肾上腺素诱导高血糖和四氧嘧啶糖尿病小白鼠 ,以 0 .5和 1.0g·kg 1 仙鹤草浸膏灌胃给药 ,对照组给予相同体积纯化水 ,观察给药后的降血糖作用。结果 :仙鹤草连续给药 4～ 7d ,可显著降低正常小白鼠血糖 ,与纯化水对照组比较 ,血糖降低水平差异有极显著性 (P <0 .0 1) ;仙鹤草连续给药 7d ,可显著抑制肾上腺素诱导的小白鼠血糖升高 ,与纯化水对照组比较 ,差异有极显著性 (P <0 .0 1) ;仙鹤草能明显降低四氧嘧啶糖尿病小白鼠的血糖 ,与纯化水对照组比较 ,差异有极显著性 (P <0 .0 1)。结论 :仙鹤草降血糖作用显著。

Objective:To study the effect of herba agrimoniae(HA) on blood glucose levels in mice. Methods:Normal, adrenaline-induced hyperglycemic and alloxan-induced diabetic mice of the Kunming strain were given each distilled water,0.5 and 1.0 g·kg -1·d -1 of the extract of HA in equal volumes by gastrogavage, respectively, for 4-7 consecutive days .Blood glucose levels of the animals in the course of the experiment were monitored. Results:Administration of both high and low doses of HA was shown to strikingly lower the blood glucose levels of the normal mice(after 4-7 consecutive days of treatment) as well those of the adrenaline-induced hyperglycemic mice and alloxan-induced diabetic mice(after 7 consecutive days of treatment).The differences were all highly significant(P<0.01), as compared with the effects of distilled water. Conclusion:HA was shown to have an excellent hypoglycemic effect in mice.