灯盏花素缓释滴丸对家兔血液流变学的影响

Effect of Scutellarin Sustained-release Dropping Pills on Hemorrheology of Rabbits

目的 :研究灯盏花素缓释滴丸对家兔血液流变学的影响。方法 :家兔 16只 ,随机分为 3组 ,B组灌胃给予灯盏花素缓释滴丸 40mg·kg 1 ·d 1 ,A组给予同等剂量的灯盏花素片的混悬液 ,对照组给予 0 .9%氯化钠注射液 15mL·d 1 ,均连续给药 7d ,测定给药后的血液流变学指标。结果 :B组对家兔的全血粘度、血浆粘度、血细胞比容及红细胞变形指数的作用均强于A组。结论 :A、B组比较 ,B组具有更强的生物学效应。

Objective:To study the effect of scutellarin sustained-release dropping pills on hemorrheology of rabbits. Methods:16 rabbits were randomly divided into 3 groups: A, B and C. Rabbits of group B, A and C were given each daily by gastrogavage 40 mg·kg -1 of scutellarin sustained-release dropping pills, suspension of 40 mg·kg -1 powdered scutellarin tablets and equal amount of normal saline, respectively, for 7 consecutive days. Indices reflecting hemorrheology of the animals were then determined. Results:In comparison with scutellarin tablets, scutellarin sustained-release dropping pills were shown to have stronger effects in improving whole blood viscosity, plasma viscosity, hematocrit and erythrocyte deformation of the rabbits. Conclusion:Scutellarin sustained-release dropping pills were shown to possess stronger biological effects as compared with those of scutellarin tablets.