咪喹莫特乳膏的制备与治疗尖锐湿疣的临床应用

Preparation of Imiquimod Cream and Its Clinical Application in the Treatment of Condyloma Acuminatum

目的 :研制治疗尖锐湿疣的新型外用免疫调节药咪喹莫特乳膏 ,并观察其临床疗效。方法 :苯甲醇、异硬脂酸、十八醇等加热融化为油相 ,甘油、对羟基苯甲酸甲酯、对羟基苯甲酸丙酯等加热融化为水相 ,将油相加入水相制成乳膏基质 ,把咪喹莫特细粉加入乳膏基质制备咪喹莫特乳膏。采用紫外分光光度法测定其含量 ,并观察咪喹莫特乳膏治疗 12 5例尖锐湿疣患者的疗效。结果 :该制剂制备简单 ,质量可控 ,临床治疗尖锐湿疣患者 ,治疗 8周总有效率 97.6%。结论 :咪喹莫特乳膏是治疗尖锐湿疣的有效药物 ,可作为第一线药物应用于临床。

Objective:To prepare imiquimod cream, a neotype topical immunomodulator for the treatment of condyloma acuminatum. Methods:The oil phase was formed by melting benzyl alcohol, isostearic acid, stearyl alcohol etc. with heat, while the water phase was shaped by melting glycerol, methylparaben, propylparaben etc. with heat as well. The cream matrix was wrought by adding the oil phase into the water phase and the imiquimod cream was finished by adding fine powder of imiquimod into the cream matrix. The content of imiquimod in the cream was determined with UV spectrophotometry, and the therapeutic effectiveness of the cream in the treatment of 125 patients with condyloma acuminatum was kept under observation. Results:The preparation technology of the imiquimod cream was simple and its quality controllable. The overall effective rate of the cream in the 8 week treatment of 125 cases of condyloma acuminatum was 97.60%. Conclusion:The imiquimod cream was shown to be an effective remedy in the treatment of condyloma acuminatum and may serve as the drug of first choice clinically for combating the disease.