^(18)FDG-PET诊断孤立性肺结节的初步研究

18FDG-PET in The Diagnosis of Solitary Pulmonary Nodules (SPN)

目的:初步探讨18FDG-PET对孤立性肺结节(SPN)的诊断价值。方法:以病理组织学诊断作为金标准,回顾性分析18FDG-PET对SPN的诊断作用及假阳性和假阴性的可能原因。结果:2001年4月至2004年5月共有26例患者进入研究,18FDG-PET的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为87.0％、66.7％、84.5％、95.2％和40.0％。恶性病变组与良性病变组最大标准化摄取值(SUV)的差异没有显著性。结论:18FDG-PET诊断SPN的敏感性高,特异性低。肺结核可能是假阳性的原因;而腺癌和原发癌灶太小等可能是假阴性的原因。

Objective: To evaluate the ability of 18FDG-PET in the diagnosis of solitary pulmonary nodules(SPN). Methods: Studying the role of 18FDG-PET in the diagnosis of SPN retrospectively and analyzing some probable factors leading to false-positive diagnosis and false-negative diagnosis when pathological histology was utilized as gold standard. Results: There were 26 cases of SPN enrolled in the study, sensitivity (ST) , specificity (SP) , accuracy (AC) , positive predicting value(PPV) and negative predicting value(NPV) for I8FDG-PET in the diagnosis of SPN were 87.0%、66.7%、 84.5%、 95.2% and 40.0%. There was no significant difference between SUVmax of the maglinant group and that of the benign group. Conclusions; Sensitivity (ST) is high but specificity (SP) is low for 18FDG-PET in the diagnosis of SPN. Tuberculosis may be the main factor leading to false-positive diagnosis, and adenocarcinoma and very small primary tumor in size might lead to false-negative diagnosis.