急性脑梗死患者血浆CD_(62)p水平动态变化的研究

Changes of plasma CD_(62)p levels in patients with acute cerebral infarction

目的 :通过研究急性脑梗死患者血浆CD62 p水平的动态变化 ,探讨CD62 p在脑梗死中的作用及其水平变化与脑梗死的病情程度和预后 ,MPV ,PLT和PDW的关系。方法 :用ELISA法测定 6 0例脑梗死患者发病第 4 8h ,第 6～ 8d及第 1 5d血浆CD62 p水平 ,同时进行神经功能缺损评分评定病情程度 ,并测定MPV ,PLT和PDW。同期测定 30例健康对照者血浆CD62 p水平。结果 :脑梗死患者血浆CD62 p水平较对照组明显增高 ,差异有统计学意义(P <0 .0 1 ) ;第 4 8h血浆CD62 p水平较其它两时期高 ,差异有统计学意义 (P <0 .0 1 ) ;中、重度神经功能缺损者的血浆CD62 p水平增高程度较轻度神经功能缺损者高 ,差异有统计学意义 (P <0 .0 1 ) ;血浆CD62 p水平与SSS ,MPV和PDW成正相关 (r=0 .6 1 ,0 .5 1 ,0 .4 7,P <0 .0 1 ) ,与PLT成负相关 (r = 0 .32 ,P <0 .0 1 )。结论 :CD62 p可能参与了脑梗死并发挥重要作用 ,其水平变化与SSS ,MPV 。

Objective To explore the function of CD 62 p in cerebral infarction and the relation between the changes of its level and the severity and recovery of cerebral infarction,MPV,PDW and PLT by studying the changes of the levels of plasma CD 62 p in patients with acute cerebral infarction.Methods The levels of plasma CD 62 p were measured by ELISA in 60 patients at 48 hours,6～8 days and 15 days after ischemia, and at the same time,we evaluated neurological function deficiency score and measured MPV,PDW and PLT.The levels of 30 healthy persons mating cerebral infarction group in both sex and ages were measured. Results The levels of plasma CD 62 p in the patients with acute cerebral infarction were obviously higher than the levels of the healthy controls( P <0.001).The levels of plasma CD 62 p in CI group at 48 hours postischemia were higher than the levels at 6～8 days and at 15 days with obvious difference( P <0.01).The levels of plasma CD 62 p in the medium and the severe SSS patients were higher than the levels of the lights( P <0.001).The levels of plasma CD 62 p were positively correlated with SSS,MPV and PDW( r=0.61,0.51,0.47, P <0.01),and negatively correlated with PLT ( r= 0.32, P < 0.01 ).Conclusion CD 62 p may participate in acute cerebral infarction and play a crucial role,and the change of its levels correlates with SSS,MPV,PDW and Plt.