山羊颞下颌关节骨关节病动物模型的建立

Establishment of an Animal Model of Temporomandibular Joint Osteoarthrosis

【目的】建立颞下颌关节骨关节病动物模型。【方法】10只山羊随机分为2组,实验组以手术去除左髁状突部分软骨,术后1、2、3、5个月用内窥镜检查,组织病理切片观察2组山羊双侧关节病理改变。【结果】对照组无病理改变。实验组术后1个月,双侧关节出现轻度骨关节病表现;第5个月末,双侧关节均表现为晚期骨关节病改变,5只左侧,3只右侧关节盘穿孔。【结论】手术切除一侧关节髁状突部分软骨可导致双侧关节程度相似的骨关节病病理改变。

To establish an animal model of temporomandibular joint osteoarthrosis(TMJOA).Ten adult healthy female goats were r andomly divided into two groups of 5each.The condylar cartilages in the left side of the TMJ of the goats were r emoved in the experimental group.Arthroscopic and histologic al examination were carried out in both groups respectively in the1 st ,2 nd ,3 rd ,4 th ,5 th month after operation.An animal model of TMJOA was successfully established.It showed no significa nt pathologic change in the control g roup during every period.In the experimental group,both sides of the TMJ showed similar abnormal c hanges such as:synovial hyperplasia,vascularity and capillarectasia in the synovial membrane,denudation of the subchondral bone,and chronic infla mmation in the marrow space.5/5(100%)goats were found disc perforation in the left TM J and 3/5(60%)in the right.[Conclusion]The animal model of TMJOA established by operation in goat can reflect the developme nt of TMJOA.The damage in one side of the temporomandibular joint may induce similar path ological change in both sides of the TMJs.