血清褪黑素测定在多囊卵巢综合征诊断中的应用

Application of Determination of Serum Melatonin in Diagnosis of Polycystic Ovarian Syndrome

【目的】探讨血清褪黑素(MT)测定在多囊卵巢综合征(PCOS)诊断中的作用。【方法】通过测定PCOS患者治疗前后血清MT及其它性激素水平的变化,研究其相互关系。其中治疗前组29例,治疗组21例,对照组10例。【结果】PCOS等特定疾病的MT水平较高,均值为(77.5±57.6)mg/mL,经达因-35及克罗米芬治疗后一段时间内,其浓度无明显变化,而其他激素则变化较大,差异有统计学意义。【结论】血清MT水平对PCOS的诊断有一定的参考作用,特别是在因各种原因使用了达因-35或克罗米芬等药物、其他指标处于临界值时以及需要即时采血检测的情况下。

To investigate the significance of determining melatonin(MT )in diagnosis of polycystic ovarian syndrome (PCOS ).The changes of MT and the other sex hormones of PCOS patients before and after treatments were determined,and their relationship was investigated.The pretreatment group,treatment g roup,and control group were 29cases,21cases,and 10cases,respectively.MT levels of PCOS [mean:(77.5±57.6)mg /mL] were higher than those of the other diseases.The concentrati on of MT in blood serum did not change d istinctly after using Daine-35or Clomid,but the other hormones changed obviously.[Conclusion]The determination of MT in serum may be useful as a new assis tant diagnostic method,especially after using Daine-35or Clomid due to a lot of reasons,the oth er diagnostic determining values are in critical and instant need for taking blood sample to assay righ t away.