Tau基因A0多态性与中国人散发性帕金森病的相关性

Association Between Tau Gene A0 Poly morphism and Sporadic Parkinson' s Disease

【目的】为了探讨tau基因多态性与帕金森病的关系。【方法】本实验用PCR-片段长度多态性分析法检测了123例中国散发性帕金森病病人和114个正常对照的微管相关蛋白(tau)基因A0等位基因多态性。【结果】我们发现tau基因A0等位基因和A0/A0基因型在帕金森病组的出现率略高于对照组,分别为77.6%:74.1%和61%:57%,但无统计学意义。【结论】A0多态性与我国散发性帕金森病发病无关。

To study whether or not the tau gene polymorphism plays a role in idiopathic Parkinson's disease(IPD).Tau gene A0polymorphism was studied by polymerase chain reaction-amplifi cation fragment length polymorphis m(PCR-AFLP)in 123sporadic PD patients and 114normal controls.Although higher frequency of allele A0(77.6%vs74.1%)and genotype A0/A0(61%vs57%)were observed in PD patients compare d with controls,the differences were not statistically significant.[Conclusion]The result suggests that A0polymorphisms of tau gene is not rela ted to the pathogenesis of sporadic P arkinson' s disease.