卵巢上皮癌中HLA-DR及HLA-ABC表达的临床意义

Clinical Significance of Expression of HLA-DR and HLA-ABC Antigens in Epithelial Ovarian Carcinoma

【目的】研究卵巢上皮癌(EOC)中HLA-DR及HLA-ABC的表达及其临床意义,为以HLA为靶点的肿瘤免疫治疗提供理论依据。【方法】应用免疫组织化学SP法检测57例卵巢上皮癌、35例卵巢良性上皮肿瘤及20例正常卵巢组织中HLA-DR及HLA-ABC的表达情况。【结果】①卵巢癌HLA-DR阳性率(33/57)显著高于良性肿瘤(4/35)及正常卵巢组织(1/20),P<0.05;Ⅰ期卵巢癌HLA-DR的阳性率显著高于Ⅲ期与Ⅳ期,P<0.01;高分化组HLA-DR的阳性率显著高于中、低分化组,P<0.05。②卵巢癌HLA-ABC的阳性率(37/57)显著低于良性肿瘤(30/35)及正常卵巢组织(20/20),P<0.05;Ⅰ期卵巢癌HLA-ABC的阳性率显著高于Ⅲ期与Ⅳ期,P<0.01。③HLA-DR及HLA-ABC的阳性率与卵巢癌患者的生存率均呈正相关,阳性表达组的生存率明显高于阴性组,P<0.05。【结论】HLA-DR、HLA-ABC异常表达可能与卵巢癌的发生发展有关;HLA-DR及HLA-ABC可以作为评估卵巢癌预后的指标之一。

To investigate the significance of HLA-DR and HLA-ABC antigen expression in ovarian epithelial carcinoma and to provide the theoretic al basis on tumor immune therapy targeting HLA.Streptomyces avidin-peroxidase(S-P)immunohistochemical method was used to detect the HLA-DR a nd HLA-ABC antigen expression in normal ovarian tissues,benign and ovarian carcinomas.①The positive rate of HLA-DR in ovaria n carcinomas was obviously higher than those in benig n ovarian tumor and normal ovarian tissues,which was obviously higher in stageⅠthan that in stageⅢ&Ⅳ;The positive rate of HLA-DR was obviously higher in high differentiated group than those in m edian and low differentiated groups.②The positive rate of HLA-ABC in ovarian carcinomas was ob viously lower than those in benign ovarian tumor and normal ovarian tissues,which was obviously higher in stageⅠthan that in stageⅢ&Ⅳ.③The positive rate of HLA-DR&HLA-ABC were positively c orrelated with the survival rate of o varian carcinoma.[Conclusion]The abnormal expression of HLA-DR &H LA-ABC may be associated with the pathogenesis of ovarian carcinoma.HLA-DR &HLA-ABC may be the prognostic factors of ovarian epithelial carcinoma.