醋酸麦迪霉素干混悬剂溶出度测定方法的研究

Study on The Dissolution of Cusuan Maidimeisu Ganhunxuanji

目的：研究测定醋酸麦迪霉素干混悬剂溶出度的方法。方法：采用桨法，以磷酸盐缓冲液(pH6．8)为溶剂，转速100r·min^-1，紫外分光光度法232nm波长处测定吸收度。结果：30min的溶出量不少于标示量的70％，在0．08～0．4mg·ml^-1范围内呈良好的线性关系，r=0．9993(n=5)。结论：本方法准确可靠，能满足质量控制的要求。

Objective: To study the dissolution of Cusuan Maidimeisu Ganhunxuanji. Methods: pHos - phato buffer solution (pH6. 8) was used as the dissolution medium,the rotative velocity was 100r · min-1, ultraviolet spectrophotometry was used with a max absorption peak at the wave lengh of 232nm. Results: The standard curve was linear over the range of 0. 08 -0. 4mg · ml-1,r = 0. 9993(n = 5). Conclusion :The method was simple,accurate and reliable,It can be used for the assay of Ceti-rizine hydrochloride tablets.