腹主动脉瘤中细胞黏附分子差异表达的研究

Differential expression of cell adhesion molecule gene in abdominal aortic aneurysm

目的研究腹主动脉瘤 (AAA)中细胞黏附分子的差异表达与AAA发病的关系。方法利用基因芯片技术筛查AAA和正常腹主动脉中差异表达的细胞黏附分子基因 ,再利用分子生物学方法在基因、蛋白质水平检测。结果AAA中有 3种细胞黏附分子存在差异表达 ,它们是VCAM 1,PECAM 1,TSP ,上调比率分别达到 5 7,3 6及 5 7 4倍。结论AAA中有细胞黏附分子的表达差异 。

Objective To study the differential expression of cell adhesion molecule(CAM) genes in the pathegenesis of AAA. Methods Microarray technique was applied to screen for the differential expression of CAM genes between AAA and normal aortic tissues. Results Three differentially expressed CAM genes were found in AAAs by microarray technique and molecular biology investigation, including VCAM 1, PECAM 1, TSP,with up regulating ratio of 5 683,3 601,57 406,respectively.Conclusion These abnormally up regulated CAM genes found in AAA might participate in the development of abdominal aortic aneurysms.