大骨节病核心家庭发病特点的流行病学研究

Epidemiological characters of Kashin-Beck disease in nuclear families

目的 分析大骨节病核心家庭的发病特点。方法 应用临床诊断搜集大骨节病核心家庭,根据父母患大骨节病情况将4938个核心家庭分为四种类型,结合病区类型,分析轻、中、重病区内不同核心家庭子代患病率及其家庭聚集性。结果 (1)核心家庭类型与病区类型的轻重有关;(2)中、重病区核心家庭子1代患病具有家庭聚集性;(3)仅双亲和父亲患大骨节病的核心家庭子1代具有明显的家庭聚集性;(4)双亲患大骨节病的核心家庭的子1代患病率明显高于单亲或双亲不患大骨节病的核心家庭。结论 大骨节病病区人群的患病除了与轻、中、重病区的类型有关,还可能与核心家庭双亲患大骨节病的情况有关。

Objective To understand the epidemiological characters of Kashin-Beck disease(KBD) in nuclear families,and to probe the pathogenetic mechanism and its etiology. Methods Clinical diagnosis was used to identify nuclear families in KBD areas. Based on the clinical manifestation of parents in the nuclear families, 4938 nuclear families were divided into four types. According to the seriousness in KBD areas, prevalence of offspring and family aggregation in low, middle and high prevalence areas were formed and data was analyzed. Results (1)Type of nuclear family was associated to the degree of disease seriousness in the areas. (2)There was an aggregation of disease among the offsprings in the nuclear families of medium and high prevalence diseased areas. (3)There was an aggregation of offspring in the nuclear family of both parents or father alone who were suffered from KBD. (4)The prevalence of offspring in nuclear family of both parents with KBD was obviously higher than that in the nuclear family with single parent or neither having KBD. Conclusion The degree of diseased areas seemed to influence the seriousness of KBD in individuals. The prevalence of parents in nuclear families might play a role in the pathogenesis of KBD.