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选择性脑灌注最适温度的实验研究 被引量：3

Experimental Study of Optimum Hypothermia for Selective Cerebral Perfusion
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摘要 目的　研究选择性脑灌注最适宜温度范围。方法　应用选择性脑灌注模型对 2 4只杂种狗在适宜灌注流量和灌注压下改变不同温度进行选择性脑灌注 90min后 ,通过上矢状窦 (SSS)内不同阶段的静脉血乳酸测定、脑体感诱发电位 (SEP)的连续监测及脑皮质组织病理学的检查来评估脑保护的情况。结果　在 2 0～ 32℃范围内 ,未出现明显的脑功能及组织的不可逆损害。结论　选择性脑灌注在适宜的灌注流量及压力下 ,其温度维持在 2 0～32℃对脑保护是安全有效的 。 OBJECTIVE Selective perfusion(SCP) for hypothermic cerebral protection in cardiopulmonary bypass .METHODS This study aimed at investigating the range of optimum hypothermia for cerebral protection by performing selective cerebral perfusion in 24 mongrel dogs for 90 minutes at different temperatures.RESULTS To evaluate the results of cerebral protection,venous blood lactate levels during different periods in superior sagittal simus (SSS) were measured,cerebral cortex histopathology was evaluated and somatosensory evoked potential(SEP) was monitored continuously.CONCLUSION Those results suggest that when selective cerebral perfusion was performed,with moderate flow rate and pressure,the safe and effective range of hypothemia for brain protection is from 20℃ to 32℃. Compared with deep hypothermia,moderate hypothermia can decrease the damage to brain obviously.
作者 吴维伟 李俊 徐建军 曹秀华 崔秀明
机构地区 大庆油田总医院心胸外科
出处 《中国体外循环杂志》 2004年第3期159-162,147,共5页 Chinese Journal of Extracorporeal Circulation
关键词 选择性脑灌注 脑保护 实验研究 脑皮质 适宜 灌注压 上矢状窦 体感诱发电位 静脉血 灌流 hypothermia cerebral protection cardiopulmonary bypass selective cerebral perfusion
分类号 R654.2 [医药卫生—外科学]
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参考文献11

  • 1[1]Sakurada T, Kazai T,Tanaka H, et al. Commparative Experimental study of Cerebral Protectim During Aortic Arch Re - construction[J]. Ann Thorac Surg. 1996;61:1348 - 1354.
  • 2[2]Tanaka H, et al. Experimental study on the optimum Flow Rate and pressure for selective cerebral perfusion [J]. Ann Thorac surg 1995,59:651 - 657.
  • 3[3]Mori A sono J. Nakashima M. et al. Application of pulsatile cardiopulmonary bypass for profound hypothermia in cardiac surgery[J]. JpncircT, 1981,45:315 - 322.
  • 4[4]Bloodwell RD. Hallman GL. Cooley DA. et al , Total replacement of the aortic arch and the "subclavian steal" phenomenon[J]. Ann Thorac surg, 1968,5:236 - 245.
  • 5[5]Cyawford ES, Saleh SA, Schuessler JS, et al. Treatment of aneurysm of transverse aortic aich [J]. J Thorac ardiovasc surg1979 ;78 ;383 - 393.
  • 6[6]Andersen k. Waaben J. Husum B. et al , Nonpulsatile cardiopulmonary bypass disrupts the rlow metabolism couple in the brain [J]. J Thorac C ardiovasc surg , 1985 ;90; 570 - 579.
  • 7[7]Henriksen L. Hjelms E. Lindeburgh T. et al. Brain hyperperfusion during cardiac operations. Cerebral blood flow measured in man by intra -arterial injection of xenon 133 :evidence suggestive of intraoperative microembolism [J]. J Thorac Cardiovasc surg, 1983,86:202-208.
  • 8[9]Markand ON, Warren CH, Moorthy SS, et al. Monitoring of multimodality evoked potentials during open heart surgery under hypothermia [J]. Electroen cephalogr clin Neurophysiol,1984, 59:432 -440.
  • 9[10]Wilson GJ, Rebeyka IM, Coles JG, et al. Loss of the somatosensory evoked response as an indicator of reversible cerebral ischemia during hypothermia, low - flow cardiopulmonary bypass[J]. Ann Thorac Surg 1988,45:206 -9.
  • 10[11]Michenfelder JD. Anesthesia and the brain, 1st ed [M]. New York: Churchill Livingstone, 1998,3 - 34.

同被引文献40

  • 1DITSWORTH D, PRIESTLEY M A, LOEPKE A W, et al. Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets[J]. Anesthesiology, 2003, 98 (5): 1119- 1127.
  • 2HALSTEAD J C, ETZ C, MEIER D M, et al. Perfusing the cold brain: optimal neuroprotection for aortic surgery [J]. Ann Thorac Surg, 2007, 84 (3) : 768-774.
  • 3MORALES D L, SCULLY P T, BRAUD B E, et al. Interrupted aortic arch repair : aortic arch advancement without a patch minimizes arch reinterventions [ J ]. Ann Thorac Surg, 2006, 82 (5): 1577-1583.
  • 4DE BRUX J L, STRONG M D, PEGIS J D, et al. Retrograde cerebral perfusion : anatomic study of the distribution of blood.to.the.brain [J]. Ann Thorac Surg, 1995, 60 (4): 1294-1298
  • 5ASOU T, KADO H, IMOTO Y, et al. Selective cerebral perfusinn technique during aortic arch repair in neonates [ J ]. Ann Thorac Surg, 1996, 61 (5): 1546-1548.
  • 6HOFER A, HAIZINGER B, GEISEISEDER G, et al. Monitoring of selective antegrade cerebral perfusion using near infrared spectroscopy in neonatal aortic arch surgery [J ]. Eur J Anaesthesiol, 2005, 22 (4): 293-298.
  • 7OPPIDO G, NAPOLEONE C P, TURCI S, et al. Moderately hypothermic cardiopulmonary bypass and low-flow antegrade selective cerebral perfusion for neonatal aortic arch surgery[J]. Ann Thorac Surg, 2006, 82 (6): 2233-2239.
  • 8PIGULA F A, NEMOTO E M, GRIFFITH B P, et al. Regional low-flow perfusion provides cerebral circulatory support during neonatal aortic arch reconstruction [J ]. J Thorac Cardiovasc Surg, 2000, 119 (2): 331-339.
  • 9CHOCK V Y, AMIR G, DAVIS C R, et al. Antegrade cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet model of cardiopulmonary bypass [J]. J Thorac Cardiovasc Surg, 2006, 131 (3): 659-665.
  • 10STRAUCH J T, SPIELVOGEL D, LAUTEN A, et al. Optimal temperature for selective cerebral perfusion [J ]. J Thorac Cardiovasc Surg, 2005 , 130 (1) : 74-82.

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中国体外循环杂志
2004年 第3期

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