摘要
对３０只兔胆总管（ＣＢＤ）进行在体急性加压实验，并与正常对照组（ｎ＝５）进行比较，探讨ＣＢＤ内压力与其组织构筑的关系。结果显示：兔ＣＢＤ内平均基础压为１．２７±０．４７ｋＰａ，在基础压上增加１．９５ｋＰａ，ＣＢＤ全部破裂。正常兔ＣＢＤ直径为１．３１±０．２０ｍｍ，随着腔内压力的增高，ＣＢＤ直径增大达６．４４±０．７５ｍｍ。组织学观察发现：随着腔内压力升高，胆管上皮由高柱状变为矮柱状，着色加深，弹力纤维和胶原纤维张力增高，直至完全断裂。本研究结果提示，临床上胆道高压一般不会导致维持胆管张力与弹性的纤维发生断裂而出现疤痕修复，当胆压恢复、胆流通畅后，这种扩张的胆管可望有较好的形态与功能的恢复。
In the present research we made a thorough study of the relation between the internal pressure of common bile duct(CBD) of rabbits and their histological structure by way of adding sudden pressure to rabbits' CBD in vivo. It was found that the mean basic pressure was 1. 27±0. 47kPa,and the diameter of CBD of normal rabbits was 1. 31± 0. 20mm. In experiment group 6 of the CBD of rabbits ruptured completely,and their collagenous and elastic fibres were broken. Results suggested that clinically the high binary pressure was unlikely to cause rupture of the fibres which maintain the tension and elasticity of bile duct,and to induce the consequent repair with scar.
