摘要
分析临床及病理资料相似的乳腺癌术后长期存活组（ｎ＝２０）和２年内复发组（ｎ＝２０）细胞核ＤＮＡ含量。结果：两组按临床分期，Ⅰ、Ⅱ期与Ⅲ期间的ＤＮＡ含量相差显著（Ｐ＜０．０５）；按病理组织学分级，各组间均有非常显著的差异（Ｐ＜０．０１）。２０对配对病例中，１４对ＤＮＡ含量相差显著，复发者明显高于存活者（Ｐ＜０．０５）；另６对无显著差异（Ｐ＞０．０５）。由此提示，在影响乳腺癌预后的诸因素中，ＤＮＡ含量为独立的标示预后的生物学因素；而正确选择术式和规范手术操作也是提高乳腺癌生存率的重要因素。
The DNA contents of breast carcinoma specimens were determined in patients with longterm survival group (n= 20)and the group of recurrence within 2 years (n= 20), the clinical and pathological parameters were similar in 2 groups. The results showed that there were the significant differences in DNA content between different clinical stages(stage Ⅰ vs stage Ⅲ and stage Ⅱ vs stgae Ⅲ) (P < 0. 05),and also in all different groups according to their histo-pathological grades (P<0. 01). 14/20 matched-pair cases showed DNA content difference significantly,that of recurrence cases showed higher content than that of survival ones (P<0. 05), and another 6 matchedpairs showed no difference (P> 0. 05), It is concluded that the DNA content is an independent biological prognostic factor in breast cancer, and properselection of operative method with standardized surgical technique is also important in improving the suvival rate of the patients with breast carcinoma.
