辛伐他汀改善老年人脑动脉血流动力学的临床研究

CLINICAL STUDY OF ELDERLY BRAIN ARTERIAL HEMODYNAMICS IMPROVED BY SIMVASTATIN

目的 辛伐他汀对老年人的调脂作用和改善脑动脉血流动力学效果.方法 55例年龄60岁以上血清胆固醇>5.7mmol/L(220mg/dl)为研究组,55例年龄60岁以上血清胆固醇<5.2mmol/L(200mg/dl)者为对照组.研究组服用辛代他汀每日5mg,16周后重复血脂和脑动脉血流动力学检查.结果 研究组血清胆固醇从7.46 ±0.85降至5.73±0.90(P<0.01),甘油三脂从1.85±103降至1.70±0.88(P>0.05),低密度脂蛋白从5.97±0.86降至3.55±0.92(P<0.01).脑动脉血流动力学参数在治疗后均有改善,如血流速度平均值(左侧)由20.78±6.43增至21.97±5.29(P<0.01),脑血管外周阻力(左侧)由75.72±22.99降至64.73±20,69(P<0.01).结论 辛伐他汀治疗16周可以通过降低血管阻力增加血流量改善脑血管供血状态.

Objective Efficacy of simvastatin on modulating lipid and improving brain arterial hemodynamics in elderly was studied. Methods The study group consisted of 55 cases with age ovev 60 and serum cholesterol> 5.7mmol/L(220mg/dl) ; the control group consisted of 55 cases with age over 60 and serum cholesterol < 5. 2mmol/L(200mg/dl) . Simvastatin was administered to the study group with 5 mg/day 16 weeks later, blood lipids and brain arterial hemodynamics were tested repeatedly. Results In study group, serum cholesterol dropped from 7.46 ±0.85 to5.73±0.90(P<0.01).triglyceridefrom 1 .85 ±1.03 to 1.70 ± 0.88 ( P > 0.01) . Parameters of brain arterial hemodynamics improved after treatment, such as average blood flow (left side) increased from 20.78± 6.43 to 21.97 ±5 .29 ( P < 0.01) , brain perivascular obstruction dropped from 75 .72 ± 22.99 to 64.73 ± 20. 69(P<0.01). Conclusions Simvastatin, after 16 weeks of treatment, can be lower vascular obstruction, increase blood flow, and thus improve brain blood supply.