摘要
目的 观察慢性阻塞性肺疾病(COPD)患者在急性加重期和缓解期血清IL-6和IL-8水平的变化,以寻找有助于临床判断预后和考核疗效的参考指标.方法 双抗体夹心ELISA.结果 从总体分析,31例急性加重期COPD患者IL-6水平为63.8±32.5μg/L,明显高于缓解期54.9±23.4μg/L(P<0.05);33例COPD急性加重期患者IL-8水平为195.9±171.5μg/L,也明显高于缓解期131.4±153.1μG/L(P<0.05).但患者个体水平有很大差异,在COPD从急性期转为缓解期时,38.7%患者的IL-6水平明显下降,而IL-8水平明显下降者占72.2%.结论IL-8是COPD急性加重期感染的一个重要指标,其临床实用价值高于IL-6.
Objective To study the level of serum concentration of interleukin - 6 (IL - 6) and interleukin -8 (IL- 8) in patients with chronic obstructive pulmonary diseases (COPD) in acute stage and in remission stage. Methods Dorble antibody sandwich ELISA. Results The value of serum IL - 6 in acute stage COPD (63 .8 ±32.5μg/L) was significantly higher than those in remission stage (54.9 ± 23 .4μg/L. P < 0.05) . The value of serum IL - 8 in acute stage (195 .9± 171 .5 μg/L) was also significantly higher than those in remission stage ( 131 . 4± 153. 1μg/L, P < 0.05) . When COPD patients improved from acute to remission stage, the serum IL - 8 decreased (72 .2% ) more than that of IL - 6 (38 .9 % ) . Conclusions Serum IL - 8 is a mote important indicator for acute infection in COPD.
出处
《老年医学与保健》
CAS
1999年第1期30-31,34,共3页
Geriatrics & Health Care
