嗜麦芽窄食单胞菌耐药性分析

Analysis of stenotrophomonas maltoppilia' s drug resistance

目的:分析嗜麦芽窄食单胞菌的耐药性以指导临床合理用药。方法:对经VITEK系统鉴定出101株嗜麦芽窄食单胞菌进行自动化药敏试验和纸片扩散法药敏试验,同时对长期难治性嗜麦芽窄食单胞菌感染患者每间隔1周进行1次药敏试验。结果:在所有临床标本中从痰液分离的嗜麦芽窄食单胞菌最多(75％),其次是洁尿(10％),该菌对亚胺培南天然耐药,氨苄西林、阿莫西林/棒酸、头孢唑啉、呋喃妥因、头孢呋辛为100％耐药。丁胺卡那、氨曲南、头孢美唑、头孢曲松、头孢噻肟、庆大霉素敏感率在20％以下,对左氧氟沙星、复方新诺明、头孢他啶、头孢哌酮/舒巴坦(舒普深)耐药率分别为18.92％、22.86％、13.95％、2.50％。结论:嗜麦芽窄食单胞菌为医院感染的重要病原菌,对大多数抗生素耐药,头孢哌酮/舒巴坦(舒普深)为其首选药物;嗜麦芽窄食单胞菌对仅有的几个敏感药物也易产生药物诱导性耐药。

Objective:To analyse the drug resistance of the stenotrophomonas maltophilia in order to guide rational drug using in clinical. Methods: The automatic drug sensitive test and method that the paper spreads medicine sensitive test were carried on to 101 stems of the stenotrophomonas maltophilia with the index of the VITEK system, and drug sensitive test with long-term difficult to treat nature's stenotrophomonas maltophilia infection patient was carried once a week. Results:In all clinical samples,stenotrophomonas maltophilia separated from phlegm liquid is the most (75% ) , then is the clear urine( 10% ) ,this fungus is nature resistance to the action of the iminepinan. The drug resistance of ampicillin,amoxicillin/clavulanic acid,cefazolin,furantoin,cefuroxime are 100% . Amika-cin, aztreonam, cefmetazole, ceftriaxone, cefotaxime, gentamicin's sensitive rate are under 20% , for levofloxacin, Compound sinomin, ceftazidime,cefoperazone/sulbactam,the drug resistance is 18.92% ,22.86% ,13.95% ,2.50% respectively. Conclusion:Stenotrophomonas maltophilia is the important pathogen fungus that infects in hospital, and resistance to most of the antibiotics, Cefoperazone/sul-bactam is the first-selected medicine for it; Stenotrophomonas maltophilia is easy to produce medicament inductivity resistance to a few sensitive drugs.