聚丙烯酸型高吸水树脂缓泻作用研究

Laxative effect of sodium polyacrylate

目的:探讨聚丙烯酸型高吸水树脂的缓泻作用。方法:采用小鼠胃肠推进运动实验、小鼠小肠保水实验和对小鼠便秘模型作用实验,并对实验数据进行统计分析。结果:聚丙烯酸型高吸水树脂可使小肠推进距离和小肠推进率增加并显著高于对照组(P<0.01);聚丙烯酸型高吸水树脂组小肠重量明显高于空白对照组(P<0.01),表明聚丙烯酸型高吸水树脂可增加肠道水分;聚丙烯酸型高吸水树脂使便秘小鼠排便粒数显著高于便秘模型组(P<0.01)。结论:聚丙烯酸型高吸水树脂在一定剂量下具有缓泻作用。

Objective: To investigate if sodium polyacrylate, a kind of superabsorbent polymer widely used in infant diaper and feminine napkin, has laxative effect. Methods: Mice bowel motion test and keeping water test were carried out and mice constipation models were treated. Results: It was found that sodium polyacrylate could increase intestine motion significantly and make intestine keeping more water than placebo,and treat constipation effectively. Conclusion:Sodium polyacrylate has laxative effect.