甲硝唑乳膏的制备及质量控制

Preparation and quality control of metronidazole cream

目的:制备甲硝唑乳膏并建立其质量控制标准。方法:以甲硝唑为主药制备甲硝唑乳膏,采用紫外分光光度法测定甲硝唑乳膏中甲硝唑的含量。结果:甲硝唑的平均回收率为100.2％,RSD为1.7％。结论:该制剂处方及工艺具有生产可行性,其质量控制标准符合《中国药典》要求,含量测定方法简单、快速、准确。

Objective: To prepare metronidazole cream and establish quality control standard. Methods: The cream was prepared by taking metronidazole as main components. The contents of metronidazole was determined by UV spectrometry. Results:The average recovery of metronidazole was 100. 2% , RSD was 1. 7% . Conclusion:The cream can be prepare feasibly. The method of quality control is simple,rapid and accurate.