应用孕妇血清标记物产前筛查胎儿唐氏综合征的初步报告

Preliminary report of prenatal screening for down syndrome by using of maternal serum markers

目的 :初步分析孕妇血清标记物甲胎球蛋白 (AFP)和绒毛膜促性腺激素β亚基 (β- HCG)在胎儿唐氏综合征的产前筛查中的作用。方法 :采用酶联免疫吸附法检测 15～ 2 0孕周孕妇血清 AFP和 β- HCG浓度 ,结合孕妇年龄、孕周 ,利用计算机软件计算胎儿患唐氏综合征风险。结果 :筛查 335例孕妇 ,筛出唐氏综合征高危孕妇 2 1例 ,占 6.2 6%。结论 :孕妇血清标记物筛查检测能显著降低需要进行创伤性产前诊断的高龄孕妇比例 ,随着筛查标本量的扩大 。

Objective:To investigate the effect of maternal serum markers AFP HCG for prenatal screening of down syndrome Methods:Used a method based on detecting maternal serum alpha fetoprotein(AFP) and free beta human chorionic gonadotrophin(β-HCG)concentrations in the women of 15～20 weeks pregnance in combination with maternal age and gestational age Pregnant women at risk for fetal DS were identified by analyses of computer software Results:Among 335 pregnant women,21 cases (6 26)were at high rish risk for DS Conclusion:Prenatal screening can reduce the need for invasive prenatal diagnosis in women 35 years With the increase of sample,prenatal screening can provide sudstantial advantages for down syndrome 〔