孕妇广泛焦虑障碍和血浆DA、NE、5-HT的相关研究

A relative study of plasma DA, NE and 5 HT with pregnant women with generalized anxiety disorder

目的 :探讨分娩前孕妇广泛性焦虑障碍与血浆 5 - HT、DA、NE的关系。方法 :首先用心理卫生量表 (SAS、SDS、HAMA、HAMD)筛查孕妇中存在广泛性焦虑和抑郁共病共 4 6例。研究组血浆中五羟色胺 (5 - HT4 6例 )、去甲肾上腺素 (NE4 6例 )、多巴胺 (DA4 5例 )和正常对照组 (5 - HT、DA、NE各 2 0例 )由苏州大学生化工程研究所采用高效液相色谱仪、电化学检测器进行测定。结果 :分娩前孕妇广泛性焦虑障碍血浆 5 - HT、DA、NE和对照组未见明显差异。讨论 :我们在产前经 SAS、HAMA检测发现产前孕妇广泛性焦虑障碍有 74例。我们选择了资料完整诊断明确的产前广泛性焦虑进行了血浆 5 - HT、NE、DA测定结果发现与对照组没有明显差异 ,这说明孕妇在临床上焦虑症状明显 ,但体内血浆神经介质极不稳定 ,神经介质变化在人体内较为复杂 ,使两者没有变化 ,提示孕妇广泛性焦虑障碍患者存在外周交感神经兴奋性增高 ,血浆 5 - HT、NE、DA浓度不能鉴别焦虑症。以上观点还需进一步研究。在妇产科广泛焦虑障碍这一疾病 ,应引起产科医师注意。

Objective: To study the relationship of pregnant women with generalized anxiety and plasma 5 HT, DA, NE Methods:The psychological scales such as SAS, SDS, HAMA and HAMD have been used to screen and find 46 pregnant women with generalized anxiety and depression coexisting disorder.The study group of plasma 5 HT (46 cases), NE (46 cases), DA (45 cases) and normal control (20 cases of 5 HT, DA, NE respectively) were measured by the high performance liquid chromatography (HPLC) and electrochemical detector in chemical engineering institute in Suzhou university Results:No significant difference was found between the study group and the control group Conclusions:74 cases with generalized anxiety disorder were found by SAS and HAMA No difference between the study group and the control group indicated that pregnant women have obvious symptoms but less change of neurotransmitters because of their high instability and complicated change in human body This also meant the excitement of peripheral sympathetic nerves in pregnant women will increase and the plasma of 5 HT, NE and DA can't used to differentiate the anxiety disorder The above view still needs further research The disease of generalized anxiety disorder should cause the attention of obstetrician 〔