摘要
目的 探讨不同糖耐量孕妇血清脂联素与胰岛素抵抗和胰岛 β细胞分泌功能的关系。 方法 2 0 0 3年1月至 2 0 0 4年 1月广东省妇幼保健院和佛山市妇幼保健院采用稳态模型评估法 (HOMA)分别评估正常糖耐量孕妇 (NGT)、糖耐量减低孕妇 (GIGT)和妊娠期糖尿病患者 (GDM)的胰岛素抵抗指数 (HOMA IR)和胰岛 β细胞功能指数 (HBCI) ;利用放免法检测三组孕妇的血清脂联素水平。结果 (1)GDM组HOMA IR显著高于GIGT组 (P <0 0 5 )和NGT组 (P <0 0 0 1) ,三组的HBCI则差异无显著性。 (2 )血清脂联素水平由NGT、GIGI到GDM呈逐步下降态势 (P <0 0 0 1) ;多元回归分析提示HOMA IR、孕晚期体重、孕晚期BMI是影响血清脂联素水平的最显著因素(r2 =0 4 84 ,P <0 0 0 1)。结论 GDM和GIGT患者血清脂联素显著降低 ,并以GDM降低最为明显 ;其脂联素水平的改变与胰岛素敏感性高度相关。
Objective To explore the relationship between adiponectin and insulin resistance and β-c ell function.Methods Homeostasis model assessment (HOMA) was adopted to evaluate IR index and β-cel l function index in the pregnancies with different glucose tolerance.And radioimm unoassay was applied to detect the serum adiponectin level in these three groups from Jan.2003 to Jan.2004. Results (1)HOMA-IR in the GDM group was significantly higher than those in the GIGT gro up (P<0\^05) and the NGT group (P<0\^001),but there was no significant d ifference in the HOMA-β among three groups.(2)In the NGT,GIGI and GDM group,th e serum adiponectin level tended to decline gradually in turn (P<0\^001).The multivariate regression analysis revealed that the serum adiponectin was correla ted significantly with FBG,third-trimester weight and third-trimester BMI(r 2=0\^484,P<0\^001).Conclusion The serum adiponectin level in the GDM and GIGT patients decreases significantly ,especially in the GDM cases,and its change is significantly negatively associat ed with IR.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2004年第10期615-617,共3页
Chinese Journal of Practical Gynecology and Obstetrics
基金
广东省医学科学技术研究基金资助项目 (A2 0 0 3 0 97)