摘要
为探讨妊娠期糖尿病患者胰岛素抵抗与细胞内钙代谢失常的关系 ,对 32例妊娠糖尿病组及 4 7名正常妊娠组 ,4 3名非妊娠组红细胞内Ca2 + 浓度和红细胞胰岛素受体酪氨酸激酶 (TPK)活性进行测定。结果显示 ,妊娠期糖尿病患者红细胞内Ca2 + 浓度显著高于正常妊娠组和非妊娠组 (P <0 .0 1)。相关性分析显示 ,妊娠期糖尿病患者红细胞内Ca2 + 浓度与空腹血糖 (r =0 .4 18)空腹胰岛素 (r =0 .36 7)显著正相关 ,与胰岛素受体TPK活性(r =- 0 .874 )显著负相关 ,均有显著性差异 (P <0 .0 1)。研究表明 :妊娠期糖尿病患者红细胞内钙含量变化 ,可能是导致妊娠期糖尿病胰岛素抵抗的原因之一。
To invesigate the relationship between the inslulin resistance(IR) and abnormalities of cellular calcium metabolism in gestational diabetes mellitus, the changes in the [Ca 2+ ]i and the insulin receptor tyrosine kinase activity in circulating erythrocytes of 32 cases gestational diabetes were compared with those of 47 normal pregnant and 43 non pregnant women.The level of [Ca 2+ ]i in circulating erythrocyte in gestational diabetes mellitus women was significantly higher than that in the pregnant and non pregant women(P<0.01); but the level of insulin receptor tyrosine kisase activity was significantly decreased in gestational diabetes millitus(P<0.01).The [Ca 2+ ]i in circulating erythrocytes in gestational diabetes mellitus was positively correlated with fasting blood glucose and fasting insulin, negatively with the insulin receptor tyrosine kisase activity(P<0.01); The change of [Ca 2+ ]i level during the gastational period might be one of the possible factor in the insulin resistance of gestaional diabetes mellitus.
出处
《标记免疫分析与临床》
CAS
2004年第3期140-142,共3页
Labeled Immunoassays and Clinical Medicine
