放免法测定产后抑郁症患者血清雌孕激素水平分析

Research of the Changes of Serum Level of Estradiol and Progesterone in Patients with Postpartum Depression by RIA

为研究妊娠 2 8- 32周、产后 1周及产后 4周血清雌二醇 (E2 )、孕酮 (P)水平变化与产后抑郁症的关系 ,用抑郁自评量表和焦虑自评量表分别评定 2 0 0例产妇的抑郁和焦虑情绪 ,并用放免法测定孕妇产前、产后的血清E2 和P含量。结果显示 :2 0 0例产妇抑郁情绪发生率为 11% ,焦虑情绪的发生率为 14 %。产后抑郁症产妇产前血清E2 、P水平与无产后抑郁症产妇相比无显著差异 (P >0 .0 5 ) ;产后抑郁症E2 水平显著低于对照组 (P <0 .0 5 ) ,产后 1周、4周E2 水平与产前的差值 ,抑郁组明显高于对照组 (P <0 .0 5 ) ,产后抑郁组P水平下降慢于对照组。研究表明 ,产后E2 、P水平的改变与产后抑郁症的发生有关。

The relationship of the changes of hormone in patients with postpartum depressive disorder on 28-32 weeks of pregnancy, 1 week and 4 weeks postpartum was studied.Depress affection and anxious affections were measured in 200 postpartum women by self rating depression scale and self rating anxiety scale.Serum estradiol(E 2) and progesterone(P) levels in postpartum women were measured by RIA with control group.Results showed that the prevalence rate of depress affection was 11% and that of anxious affection was 14%. The serum levels of P on the 1 week postpartum, E 2 in anteportum were showed higher in the depressed group compared with control group.There was a significant difference in the changes of serum E 2 before and after delivery between the depressed group and control group(P<0.05).The results suggested that there was a difference in the hormone changes in E 2 and P levels in the patients with postpartum depression after delivery.