尿毒症患者精子形态学变化的研究

Changes in morphology of semen of the uremic patients

目的了解尿毒症患者精子形态学及多重精子缺陷指数的变化。方法对25例尿毒症患者和12例正常男性的精液进行精子形态学和多种异常指数(MAI)及精子畸形指数(SDI)的分析。结果尿毒症组头部畸形精子的百分率为(66.21±13.57)%、SDI为1.38±0.25,与正常男性比较差别有显著性意义(P<0.01)。MAI为1.52±0.21,与正常男性比较差别无显著性意义(P>0.05)。结论上述变化与尿毒症引起促性腺激素分泌异常有关,也可能与尿毒症患者体内某些毒素对睾丸生精系统和附睾精子成熟环境的不良影响有关。

Objective To observe the changes in morphology, multiple anomalies index(MAI) and sperm deformity index(SDI) of sperm of the uremic patients. Methods The semen specimens were collected from 25 uremic patients and 12 normal volunteers. The sperm morphology and MAI and SDI were analyzed. Results The percentages of deformity of sperm head in uremic group were 66.21±13.57%, and the SDI of uremic patients was 1.38±0.25, significantly, compared with those of normal volunteers(P<0.01). The MAI of uremic patients was 1.52±0.21, which was no significant difference with that of normal volunteers(P>0.05). Conclusion These changes may be relate to abnormal gonadotropin secretion, or to the harmful effects of some toxins to the spermatogenesis in uremia.