耐甲氧西林葡萄球菌抗菌谱分析

Analysis antidiotic effect range of methicill resistant stathycococcus

目的 :研究出耐甲氧西林葡萄球菌 (MRS)敏感的药物 ,以用于临床感染治疗。 方法 :细菌鉴定采用APIStaph和TH 16S鉴定编码管 ,药敏试验采用ATB STAPH5 ,耐甲氧西林葡萄球菌检测用稀释法和K B法。 结果 :(1)苯唑西林金黄色葡萄球菌 (MRSA)对抗生素的耐药率为 :青霉素G (PEN ) 10 0 %、复方新诺明 (TSU )87.5 %、庆大霉素 (GEN) 87.5 %、万古霉素 (VAN) 0 %、替考拉宁 (TEC) 0 %、夫西地酸 (FUS) 2 5 .0 %、喹如普汀 达福普汀 (QDA) 37.5 %等。 (2 )凝固酶阴性葡萄球菌 (MRCNS)对抗生素的耐药率为 :苯唑西林 (OX) 10 0 %、青霉素G10 0 %、复方新诺明 82 .2 8%、庆大霉素 73.2 %、红霉素 (ERY) 94 .37%、万古霉素 0 %、替考拉宁 0 %、利福平 (RFA)12 .6 %、夫西地酸 1.4 %、呋喃妥因 1.4 %、喹如普汀 达福普 4 .2 %。以Scheffe法行多重比较 ,苯唑西林与红霉素耐药率比较差异无统计学意义 (P >0 .0 5 ) ,苯唑西林与其它抗生素比较 ,差异均有统计学意义 (P <0 .0 5 )。 结论 :MRS对磺胺类、氨基糖苷类、喹诺酮类、大环酯类等抗生素的耐药率已呈现很高的水平 ,治疗MRS菌引起的感染应选用多肽类、夫西地酸等抗生素。

Objective: To find out the susceptible medicines of MRS in order to use in clinical infection. Methods: The means to identifying bacterium are appraisal API Staph and the TH-16S' s coding tube. The antimi crobial susceptibicity testing is adoped the way of ATB-STAPH5 and MRS is examined by the way of dilution and K-B. Results: (1)The rates of the drug resistance in different antiiotic to MRSA are as lollowing: Penicillin G is 100%, SuIfamethoxazole is 87.5%, Gentamicinis 87.5%, Vancomycin is 0%, FusidicAcid is 25.0%, Levofloxacin is 37.5%. (2) The rates of drug resistance in different antiiotic to MRCNS are as following: Oxacillin is 100%, Penicillin Gis 100%, SuIfamethoxazoleis 82.28%, Gentamicinis 73.2%, Erythromycin is 94.37%, Vancomycin is 0%, Levofloxacin is 66.1%, FusidicAcid is 25.0%. The way of the statistics analysis is used with scheffe's way in all data. The rate of drug resistance comparing OX with ERY is indifferent (P>0.05) and comparing OX with others are significantly different (P<0.05). Conclusion: The rate of the drug resistance of the MRS to those antiiotic such as SuIfamethoxazole, Gentamicin are in a high level, so the antibiotics like Vancomycin, FusidicAcid should be used which is susceptible to MRS.