重组人生长激素治疗肝硬化低蛋白血症20例观察

Efficacy of Recombinant Humen Growth Hormone on Hypoproteinemia Complicated with Cirrhosis

目的 观察重组人生长激素 (r -hGH)对肝硬化引起的低蛋白血症疗效。方法 将 3 9例肝硬化病人随机分为r-hGH组 ( 2 0例 )和对照组 ( 19例 ) ,两组均给予保肝、退黄、利尿对症治疗 ,但不使用人血白蛋白、血浆及其他促进蛋白质合成和肝细胞再生的药物。r-hGH组给予r-hGH4IU皮下注射 ,每天 1次 ,共 10天 ;检测两组治疗前、后、停药 2周时血浆蛋白和肝功能。结果 血浆白蛋白由治疗前的 ( 2 8.10± 3 .0 6)g L增至 ( 3 3 .5 6± 4.13 )g L(P<0 .0 5 ) ,停药 2周时血浆白蛋白增加到 ( 3 5 .62± 6.12 )g L(P <0 .0 5 ) ,对照组无明显变化 ,两组比较有显著差异 (P <0 .0 5 )。肝功能指标在治疗后较治疗前有改善 ,但无显著差异。结论 r-hGH可以增加肝硬化病人的白蛋白合成 ,无明显不良反应。

Objective To observe the efficacy of r-hGH on hypoproteinemia complicated with cirrhosis.Methods 39 patients with hypoproteimia complicated with cirrhosis were randomly divided into rhGH group(n=20) or control group (n=19).All patients were not treated with albumin and transfusion of blood or plasma during the whole study period. The patients in rhGH group were treated with rhGH 41U once daily for 10 days. Regular liver function measurements including plasma albumin levels were assayed.Results After treatment with rhGH, the plasma albumin concentration was increased in rhGH group from(28.10±3.06)g/L to(33.56±4.13)g/L(P<0.05)and two weeks later after treatment it was increased to(35.62±6.12)g/L(P<0.05).No significant increases were seen in the control group. The plasma albumin concentrations after treatment and two weeks later after treatment between rhGH group and control group had significant differences(P<0.05).Other parameters of regular liver function measurements were improved too, but not significantly.Conclusions rhGH has capacity to promote albumin synthesis in hepatocytes and no evidence of adverse reaction was revealed.