电针心经不同经脉段对急性心肌缺血家兔心功能的影响

Effects of Electroacupuncture Stimulation of Three Segments of the Heart Meridian on Cardiac Function in Rabbits with Acute Myocardial Ischemia

目的 :比较电针心经腕段、心经肘段和心经肩段对急性心肌缺血家兔心功能的影响。方法 :将动物随机分为对照组、模型组和心经腕段组、心经肘段组、心经肩段组 ,以左心室内压峰值(LVP)、左心室内压变化上升最大速率 (LVPdp/dtmax)、心力环面积 (ACFL)、心肌收缩成分最大缩短速度 (Vmax)为指标 ,观察静脉注射脑垂体后叶素造成家兔急性心肌缺血心功能各指标的变化及电针对其的干预作用。结果 :电针心经腕段、心经肘段和心经肩段均能显著性地调节心功能 ,尤以心经腕段最为显著 ,而心经肩段的调节作用似较心经肘段为强 ,但两者比较差异不显著。结论 :心经腕段作为心经经脉一特定的经脉段 ,其调节心功能作用最具代表性。

Objective: To probe the effects of electroacupuncture (EA) stimulation of three different segments (wrist, elbow and shoulder portions) of the Heart Meridian on the cardiac function in rabbits with acute myocardial ischemia (AMI). Methods: A total of 50 rabbits anesthetized with urethane (1 g/kg) were randomized into control group, model group, EA-wrist-segment group, EA-elbow-segment group and EA-shoulder-segment group, with 10 cases in each group. AMI was induced by intravenous injection of posterior pituitary hormone (2 μ/kg+saline to 2 mL). Three different segments of the Heart Meridian were punctured and stimulated electrically with ZYZ-1 EA-Therapeutic Apparatus separately. Left ventricular pressure (LVP), maximum rising rate (dp/dtmax) of LVP, the area of myocardial force loop (ACFL) and the maximal shortening velocity of myocardium (Vmax) were used as the indexes. Results: After AMI, LVP, dp/dtmax,ACFL and Vmax in model group decreased significantly in comparison with those of control group(P<0.01), while compared with model group, values of the 4 indexes of EA-wrist-segment group, EA-elbow-segment group and EA-shoulder-segment group were significantly higher(P<0.05～0.01), values of the 4 indexes of EA-wrist-segment group were all significantly higher than those of both EA-elbow-segment group and EA-shoulder-segment group (P<0.05) , but no significant differences were found between EA-elbow-segment group and EA-shoulder-segment group in these 4 indexes. Conclusion: EA stimulation of different segments of the Heart Meridian can improve performance of the ischemic heart and the wrist segment of this meridian has a representative role.